Successful and single businesswoman Kate Holbrook (Tina Fey) has long put her career ahead of a personal life. Now 37, she's finally determined to have a kid on her own. But her plan is thrown a curve ball after she discovers she has only a million-to-one chance of getting pregnant. Undaunted, the driven Kate allows South Philly working girl Angie Ostrowiski (Amy Poehler) to become her unlikely surrogate. Simple enough. After learning from the steely head (Sigourney Weaver) of their surrogacy center that Angie is pregnant, Kate goes into precision nesting mode: reading childcare books, baby-proofing the apartment and researching top pre-schools.